Cystorelin Injection

Prescription items are NON-RETURNABLE and NON REFUNDABLE

 

Historically, cystic ovaries have responded to an exogenous source of luteinizing hormone (LH) such as human chorionic gonadotropin. CYSTORELIN^® initiates release of endogenous LH to cause ovulation and luteinization.

 

The recommended intravenous or intramuscular dosage of CYSTORELIN^® is 100 mcg (2 mL) per cow.

 

Ingredients:

Each mL of CYSTORELIN^® contains:

Gonadorelin diacetate tetrahydrate	50 mcg
Benzyl Alcohol	9 mg
Sodium Chloride	7.47 mg
Water for Injection, U.S.P.	q.s.

pH adjusted with potassium phosphate (monobasic and dibasic).

Storage:

Keep at or below 77°f, a brief excursion to 86°f permitted.

Discard Remaining Product 90 Days After First Use.

Endogenous gonadorelin is synthesized and/or released from the hypothalamus during various stages of the bovine estrus cycle following appropriate neurogenic stimuli. It passes via the hypophyseal portal vessels, to the anterior pituitary to effect the release of gonadotropins (e.g. LH, FSH). Synthetic gonadorelin administered intravenously or intramuscularly also causes the release of endogenous LH or FSH from the anterior pituitary.

Gonadorelin diacetate tetrahydrate has been shown to be safe. The LD50 for mice and rats is greater than 60 mg/kg, and for dogs, greater than 600 mcg/kg, respectively. No untoward effects were noted among rats or dogs administered 120 mcg/kg/day or 72 mcg/kg/day intravenously for 15 days.

It has no adverse effects on heart rate, blood pressure, or EKG to unanesthetized dogs at 60 mcg/kg. In anesthetized dogs, it did not produce depression of myocardial or system hemodynamics or adversely affect coronary oxygen supply or myocardial oxygen requirements.

The intravenous administration of 60 mcg/kg/day of gonadorelin diacetate tetrahydrate to pregnant rats and rabbits during organogenesis did not cause embryotoxic or teratogenic effects.

The intramuscular administration of 1000 mcg to normally cycling dairy cattle had no effect on hematology or blood chemistry.

Further, CYSTORELIN^® does not cause irritation at the site of intramuscular administration in dogs. The dosage administered was 72 mcg/kg/day for seven (7) days.